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Illumina iScan System

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Overview

The Illumina iScan system is an array scanner that supports sensitive and accurate imaging of Illumina’s array based genetic analysis products.

Technology

Illumina bead-based microarray technology uses silica microbeads. As DNA fragments pass over the BeadChip, each probe binds to a complementary sequence in the sample DNA, stopping one base before the locus of interest. Allele specificity is conferred by a single base extension that incorporates one of four labeled nucleotides. When excited by a laser, the nucleotide label emits a signal. The intensity of that signal conveys information about the allelic ratio at that locus.

Key Features

  • High throughput and rapid turnaround.
  • High performance lasers, optics and detection systems deliver sub-micron resolution.

Availability

Wide range of arrays available:

  • Infinium global screening array- 24 v3.0 kit
    • Serves as a customizable genomic tool for disease risk profiling studies, can add up to 100K genetic markers.
    • Consolidated up to date with clinical research screening markers from databases like ClinVar, CPIC andPharmGKB.
    • Array supports sequencing and CNV calling for the following sample types- blood, buccal swabs, FFPE tissue, saliva.
    • Sample throughput- 5750 samples per week
  • Infinium Asian Screening Array-24 v1.0 kit
  • Infinium Japanese Screening Array-24 v1.0 kit
  • Infinium Chinese Genotyping array-24 v1.0
  • Infinium Core 24 v1.2 kit
  • Infinium Core Exome 24 v1.4 kit
  • Infinium Exome 24 v1.1 kit
  • Infinium OmniExpress-24 v1.4 kit
  • Infinium OmniExpressExome-8 kit
  • Infinium PsychArray-24 v1.3 kit
  • Infinium Global Diversity Array-8 v1.0 kit
  • Infinium ImmunoArray-24 v2 BeadChip Kit
  • Infinium OncoArray-500K bead chip
  • Infinium QC Array-24 v1.0 Kit
  • Infinium Omni2.5-8 Kit
  • Infinium Omni2.5Excome-8 Kit
  • Infinium OmniZhongHua-8 v1.4 Kit
  • Infinium Omni5-4 v1.2 Kit
  • Infinium Omni5Exome-4 v1.3 Kit
  • Infinium Methylation EPIC BeadChip Kit
    • This array can selectively interrogate over 850K methylation sites at single-nucleotide resolution.
    • Up to eight Samples per array.
    • FFPE Tissue and low-input samples
  • Infinium Mouse Methylation BeadChip Kit
    • Infinium Mouse Methylation BeadChip enables quantitative methylation measurement at single-nucleotide resolution for understanding murine epigenetic changes.
    • The BeadChip interrogates more than 285,000 methylation sites per sample