Microarray

Microarray Core

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The UT Southwestern Microarray Core was established in 2001. Since then core has been providing cutting-edge Microarray, Immune-phenotyping and high-throughput biomarker profiling services to hundreds of investigators conducting basic and clinical research at UT Southwestern Medical Center and other institutions. Microarray  core provides centralized access to wide variety of services covering microarray, genomics and spatial transcriptomics to boost biomedical research at UT Southwestern. We offer a broad range of products and services for genomic and proteomic biomarker as described on this website. Core team is comprised of expert technicians, bioinformaticians and scientists who have decades of experience in the field of genomics and proteomics to offer extensive technical and scientific support from experiment design to data analysis. Our mission is to provide our investigators with the best biomarker profiling services to boost the scientific discoveries and innovations.

microbiome

Microbiome Core

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Overview
The human body is home to trillions of microorganisms that outnumber human cells by as much as an order of magnitude. It is becoming increasingly clear that these microbial communities, known as the “human microbiome”, have a profound impact on human health. Altered microbial communities are associated with diverse diseases such as inflammatory bowel disease, allergy, and obesity. Many of these organisms resist cultivation, making it necessary to rely on cultivation-independent approaches to identify and enumerate the members of the human microbiome. Advances in DNA sequencing technology have enabled the study of microbial community composition on the basis of genetic material from intact microbial communities. This approach is broadly termed “microbial metagenomics,” and allows microbial communities to be analyzed without cultivation. The UT Southwestern Microbiome Core facility was established in 2018. It provides microbial metagenomics services to basic and translational studies. The Core team comprises skilled technicians, bioinformaticians and geneticists with experience in the field of microbial genomics. We provide consultation and expert assistance in strategic planning, method development and data analysis. Our mission is to provide investigators with the best microbiome sequencing services to enable the scientific discoveries at UT Southwestern Medical Center. The core houses state-of-the art equipment, including Illumina NextSeq550 and MiSeqDx high-throughput sequencing systems, 10X Genomics Single Cell Solution, Oxford Nanopore MinION/Mk1c (long-read sequencing), Molzym robot for host depletion, Agilent 4200 and 2200 TapeStation, Covaris M220 Focused-ultrasonicator.

Genomics

Genomics Core

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Genomics Core facility was established in the department of Immunology in 2001. This facility provides cutting-edge Next Generation Sequencing (NGS) services to investigators conducting basic and translational research at UT Southwestern Medical Center and other institutions. Genomics core offers a wide variety of sequencing services including whole genome and custom DNA and RNA sequencing on Human, Mouse, Rat and other environmental samples. We provide centralized access to the genomics technologies to on-campus as well as off-campus research communities. Our team of expert technicians, bioinformaticians, and scientists who have two decades experience in the field of genomics provide consultation and expert assistance in strategic planning and method development and data analysis. Our mission is to provide our investigators with the best Next Generation Sequencing (NGS) services to enable the scientific discoveries in the area of Genomics. The core houses state-of-the art equipment, including Illumina HiSeq2500, HiSeq4000, NextSeq500, NextSeq550, MiSeqDx high-throughput sequencing systems, 10X Genomics Single Cell Solution, Oxford Nanopore MinION/Mk1c (long-read sequencing), Agilent 4200 and 2200 TapeStation, Covaris M220 Focused-ultrasonicator.